Human vaccines produced with animal cell technology (status 2012)

Human vaccines produced with animal cell technology (status 2012)

Further information on biopharmaceutical products present in the US and European markets can be found at: www.biopharma.com.

Virus/Infectious disease due to
Cells
Notes
Company
FDA approval
EMA approval
Trade name
Remarks
Measles Primary Chicken embryo fibroblasts live attenuated vaccine strainEnder Edmonston or Schwarz Sanofi-Pasteur 1986 ROUVAX and in combination with Measles, Mumps
Merck 2006 MMR VaxPro and in combination with Measles, Mumps and Varicella
<2008 ATTENUVAX and in combination with Rubella, Mumps and Varicella
GSK <2006 PRIORIX and in combination with with Mumps, Rubella
Crucell ? TRIVITAREN
Rubella MRC-5 diploïd cell line live attenuated vaccine strain WI RA 27/3 Sanofi-Pasteur 1988 RUDIVAX and in combination with Measles, Mumps
Merck 2006 MMR VaxPro and in combination with Measles, Mumps and Varicella
<2008 MERUVAX II and in combination with Rubella, Mumps and Varicella
GSK <2006 PRIORIX and in combination with Measles, Mumps
Crucell ? TRIVITAREN
Mumps Primary Chicken embryo fibroblasts live attenuated vaccine strain Jeryl Lynn Sanofi-Pasteur 1985 MMR vaccine and in combination with Measles, Rubella
Merck <2006 2006 MUMPSVAX and in combination with Rubella, Mumps and Varicella
GSK <2006 PRIORIX and in combination with Measles, Rubella
Crucell ? TRIVITAREN
Varicella / Chicken Pox MRC-5 diploïd cell line live attenuated vaccine strain Oka/Merck Merck 1996 2001 VARIVAX and in combination with Measles, Mumps and Rubella
GSK VARILIX
Zooster Herpesvirus MRC-5 diploïd cell line live attenuated vaccine strain Oka/Merck Merck 2006 ZOSTAVAX
Rotavirus Vero cells (African green monkey kidney cell line) live attenuated vaccine strains G1, G2, G3, G4, and G6 capsid proteins Merck 2006 2006 ROTATEQ
live attenuated vaccine strain 89-12 G1P[8] RIX 4414 GSK 2008 2006 ROTARIX
Smallpox Vero cells (African green monkey kidney cell line) live attenuated vaccine strain Dryvax Acambis/Sanofi-Pasteur 2007 ACAM2000
Human papilloma virus causing cervix cancer Yeast expression system Virus-like particle, adjuvanted vaccine strains type 16, 18 Merck 2006 2006 GARDASIL
Baculovirus expression system – insect cell line derived from trichoplusia Virus-like particle, adjuvanted vaccine strains type 16, 18 GSK 2009 2007 CERVARIX
Japanese encephalitis Vero cells (African green monkey kidney cells) inactivated vaccine strain S14-14-12 Intercell/Novataris 2009 2009 IXIARO
Influenza Vero cells (African green monkey kidney cells) Inactivated vaccine strain A H1N1 Baxter 2009 CELVAPAN
Inactivated vaccine strain A H5N1 2009 Pandemic Influenza Vaccine Baxter
Madine darby canine kidney cells Inactivated vaccine strains A H1N1, A H3N2 and B Novartis 2007 OPTAFLU
Poliomyelitis Primary monkey kidney cells inactivated vaccine strains type 1 Mahoney, type 2 MEF-2 and type 3 Sauket Sanofi-Pasteur 1966 DTPolio
MRC-5 diploïd cell line inactivated vaccine strains type 1 Mahoney, type 2 MEF-2 and type 3 Sauket Sanofi-Pasteur 1987 POLIOVAX
live attenuated vaccine strains type 1, 2, 3 GSK OPV oral Polio vaccine
Vero cell line (African green monkey kidney cells inactivated vaccine strains type 1 Mahoney, type 2 MEF-2 and type 3 Sauket Sanofi-Pasteur 1982 IMOVAX Polio
inactivated vaccine strains type 1 Mahoney, type 2MEF-2 and type 3 Sauket Sanofi-Pasteur 1990 IPOL
live attenuated vaccine strains type 1, 2, 3 Sanofi-Pasteur 1988 OPV oral Polio vaccine
inactivated vaccine strains type 1 Mahoney, type 2MEF-2 and type 3 Sauket GSK 2002 <2000 POLIORIX and part of Infanrix hexa, Infanrix penta and Pediatrix
Rabies MRC-5 diploïd cell line inactivated vaccine strain PM Sanofi-Pasteur 1980 IMOVAX Rabies
Vero cells (African green monkey kidney cells) inactivated vaccine strain PM Sanofi-Pasteur 1985 VERORAB
inactivated vaccine strain PM-1503-3M Novartis RABAVERT
Hepatitis A MRC-5 diploïd cell line inactivated vaccine Sanofi-Pasteur 1996 AVAXIM
Merck 1996 1997 VAQTA
GSK 1995 1993 HAVRIX and part of Ambirix, Twinrix,Hepatyrix combo

Abbreviations

ADA AT-III BAFF BHK BMP C-127 CA-125 CD CEA CHO CLL CTAA CTLA-4 E.coli EGF Adenosine deaminase Antithrombin-III B-cell activating factor Baby hamster kidney cells Bone morphogenetic protein Murine mammary tumor derived cell line Cancer antigen 125 Cluster of differentiation Carcinoembryonic antigen Chinese Hamster Ovary Chronic Lymphocytic Leukemia Colon tumor-associated antigen Cytotoxic T-Lymphocyte Antigen 4 Escherichia coli (bacterium) Epidermal growth factor EMA EpCAM EPO FDA FSH GAG GPIIb/IIa receptor HCG HEK 293 HER2 Receptor HGH HT-1080 IgE IGFBP3 IL-1 Receptor European Medicine Agency Epithelial cell adhesion molecule Erythropoeietin Food and Drug Administration Follicle stimulating hormone Glycosaminoglycans Glycoprotein IIb/IIa receptor Human chorionic gonadotrophin Human embryonic kidney cell line Human epidermal growth factor receptor 2 Human Growth Hormone Human fibrosarcoma cell line Immunoglobulin E Insulin-like growth factor binding protein 3 Interleukin-1 Receptor IL-X MAB MPS I MRC-5 NS0 OP-1 PSMA r-tPA RSV Sp2/0 TAG-72 TNF WI-38 Interleukin-X Monoclonal Antibody Mucopolysaccharidose I Medical Research Council 5 human fetal cells Mouse myeloma cell line (lymphoblast) Osteogenic protein 1 Prostate Specific Membrane Antigen Recombinant tissue plasminogen activator Respiratory syncytial virus Mouse myeloma cell line Tumor-associated glycoprotein 72 Tumor necrosis factor Wistar Institute 38 human fetal lung tissue

Sources/references

BIOPHARMA: Biopharmaceutical Products in the U.S. and European Markets 9th annual edition Web database by Ronald A. Rader Biotechnological Information Institute Nature biotechnology (several years, several authors) Bioprocess International: 30 years of US-approved cell culture products 2009 Recombinant Protein Therapeutics from CHO-cell — 20 years and counting CHO consortium SBE Special edition Biopharmaceutical Proteins Opportunities and Challenges John R. Birch and Yemi Onakunle From: Methods in Molecular Biology, vol. 308: Therapeutic Proteins: Methods and Protocols Edited by: C. M. Smales and D. C. James © Humana Press Inc., Totowa, NJ 2005 The Pink Sheet (several years)

Useful links

European Medicines Agency US Food and Drug Administration (FDA) list of vaccines licensed for immunization and distribution in the US

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