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ACTIP Bulletin 25

May 2001

 

In this issue:

Summary proposal FP 6

 

Recently, the European Commission presented its proposal for a next Framework Programme (FP 6). In this issue of the ACTIP Bulletin we review this proposal, both with respect to the background as with the proposed content. The article starts on page15, but first we review other, equally important news:

Deadlines for FP5 proposals;

Commission adopts Communication on precautionary principle;

New vaccine projects;

 

 

 

 

 

ACTIP website popular

 

During the month of March, the ACTIP website proved a success, with 23,769 requests and a total of 4,636 visits.

The number of unique visitors was1,026, and the repeat visitors numbered 370, visiting the site 2-4 times (202), 5-9 times (33), 10-24 times (78) and 25-49 times (57). This indicates that many people are using the website as a gateway site and a source of valuable documentation.

The majority of visitors is commercial and from the USA, followed by visitors from Japan, US educational institutions, Mexico, the UK, Denmark, Germany etc.

In the month of March, the most frequently visited page was the links page and the one with our latest position paper, followed by the members page, the news page and the secure page. With 59 hits the secure page (only for ACTIP members) is well visited. The various monographs average 30-40 visits per month.

 

 

Europe and Biotechnology

 

In February, the European Parliament (EP) appproved the revised 'deliberate release' directive 90/220 EC. This should have opened the way to approval of requests for marketing authorization of GMO plants.

 

However, the decision by six member states (France, Denmark, Italy, Greece, Austria and Luxembourg) to maintain an unoffical ban on GMO food leaves plant biotech companies at a crossroads. They pledged to maintain the ban "until effective arrangements are adopted for the traceability and labelling of GMOs". This way, the de facto moratorium, which seemed at the end of its days once the revised directive 90/220 was adopted, could be prolonged by years, leaving the plant biotechnology industry at a serious disadvantage. Some product applications are already in the regulatory pipeline since 1997.

 

Source: European Voice, March 21, 2001-04-24

On a more positive note ended a meeting of the European Council on March 23-24, 2001 during the Stockholm summit. The European Council confirmed that it consideres a competitive biotechnology-based industry as a key requirement and asset for Europe in the 21st century. The heads of government explicitly recognized the need for measures to utilize the full potential of biotechnology and to strengthen the competitiveness of the biotechnology-based industry.

 

Source: Press release EuropaBio, March 26, 2001

A similar message was supported by a large majority of the European Parliament when it approved the report of MEP John Purvis about the future of the Biotechnology Industry on March 12. The report criticises the de facto moratorium and calls upon the future European Food Safety Authority to restore consumer confidence in GM Foods.

 

Source: European Parliament Daily Notebook, March 15, 2001

 

News from the Commission

 

Deadlines for FP5 proposals

 

First half 2001

 

In the first few months of the year 2001, 6 deadlines for proposals had been scheduled. The following had been submitted:

* 110 for Accompanying Measures;

* 48 for Socio-Economic/Bioethical studies

* 21 for Research Infrastructures

* 96 for Marie Curie Training Host Sites (of which 60 in industry)

* 128 for SME measures (74 Exploratory Awards and 54 CRAFT).

In addition, 71 expression of interest for topics in functional genomics relating to human health were received.

 

Second half 2001

 

The following programmes are open for proposals:

Accompanying measures: deadlines June 12, 2001 and October 11, 2001

Marie Curie Individual Fellowships: deadlines October 10, 2001

SME Cooperative Research Awards: deadline September 19, 2001

Mechanism for the submission of joint projects under the 'Partner for Life': available until April 2002. Intended for SMEs, to support their participation in European Research Projects. See also:

 

www.bit.ac.at/partners_for_life.htm

 

Commission adopts communication on Precautionary Principle

 

On February 2, 2000, the European Commision has adopted a Communication on the Use of the Precautionary Principle.

The Communication underlines that the precautionary principle forms part of a structured approach to the analysis of risk, as well as being relevant to risk management. It covers cases where scientific evidence is insufficient, inconclusive or uncertain and preliminary scientific evaluation indicates that there are reasonable grounds for concern that the potentially dangerous effects on the environment, human, animal or plant health may be inconsistent with the high level of protection chosen by the EU.

The Communication makes it clear that the precautionary principle is neither a politicisation of science or the acceptance of zero-risk but that it provides a basis for actiob when science is unable to give a clear answer.

 

A copy of the press release and the Communication itself is available on request from the IVTIP Secretariat.

 

New vaccine projects

 

Since September last year, a number of new vaccine projects have been started in Key Action 2, Control of Infectious Diseases. Below we give the titles and the project's number. If you want to obtain an abstract of the project, you can do two things: either visit

 

http://dbs.cordis.lu/EN_PROJI_search.html,

and type in as keywords the project's number, or, if you want to see all projects supported under KA2, type in QLK2 and you get a complete listing. Alternatively, ask the ACTIP secretariat for a copy or file of the abstracts listed below.

  1. Adhesive interactions in malaria: new targets for intervention. QLK2- 2000-00109
  2. New tools to investigate and suppress HIV drug resistance. QLK2-2000-00291
  3. Development and evaluation of nucleic acid amplification methods for the detection of respiratory pathogens in community acquired pneumonia. QLK2-2000-00294
  4. Immunological mechanisms of T-cell activation by dendritic cells: a novel strategy for immune intervention. QLK2-2000-00470
  5. Immunotherapy of enteric infections by rotaviruses and coronaviruses using plantibodies. QLK2-2000-00739
  6. Development and testing of a combined antiretroviral, immune and gene therapy for treatment of HIV patients. QLK2-2000-01040
  7. Combined immune and gene therapy for chronic hepatitis. QLK2-2000-01476

 

Business News

 

Changes to EU patent system

 

On November 29, 2000, agreement was reached on a number of important amendments to the European Patent Convention. All are expected to enter into force within the next four years.

The amendments to the EPC relate primarily to the streamlining of granting procedure, in particular the language system:

  • once effective, applicants will be able to file a patent application in any of the languages of the designated countries and, if this is not one of the three official EPC languages (English, German and French), a translation into one of these need only take place at a later stage. This will reduce costs by some 50%
  • In the grant procedure, search (novelty) and examination (inventiveness) will be combined, with one examiner in principle carrying out both;
  • computer programmes remain unpatentable, but computer-implemented inventions can be patented if they involve a new and inventive technical contribution to the state of the art.

 

Celera and rivals in rat genome project

 

Celera Genomics will share a new 58 million USD grant with the Baylor College of Medicine, which was one of the five sequencing centers for the Human Genome Project. Baylor and Celera did not decide to cooperate on their own. Each applied to win the full grant, which the NIH decided to split, with about 60% going to Baylor. Dr. Venter said cooperating with government was a cost-effective way to add to its database of genetic information. Other participants in the rat project are Genome Therapeutics Corp. of Waltham, Mass., the Institute for Genomic Research in Rockville, Md and the University of British Columbia.

 

Source: New York Times, March 1, 2001

 

Drug firm's alarm over costly delays

 

A European Commission funded study has found that many pharmaceutical firms complain how the EU-wide system for drug approval and the EMEA has worked in practice, featuring many costly delays. Companies are also alarmed over the way many member states continue to ignore the alternative system, insisting that drugs accepted elsewhere still run the bureaucratic gauntlet of domestic authorisation procedures. The competent authorities do not seek to disguise the fact that there is unwillingness of member states to abide by the principles of mutual recognition, states the report.

 

Source: European Voice, January 10, 2001

 

Pharmaceutical firms attacked

 

On February 11 last, animal rights activists in the UK mounted demonstrations against pharmaceutical companies which they claimed support testing of drugs on animals at Huntingdon Life Sciences.

Hundreds of protesters were involved in a coordinated series of break-ins or demonstrations at the laboratories, offices and at the homes of directors of five leading companies: Bayer, Eli Lilly, Novartis Pharmaceuticals, Roche and Pharmacia Corporation.

The protestors hope to persuade the companies to withdraw their support from Huntingdon's laboratories in Cambridgeshire and in Occold, Suffolk. They said the demonstrations marked the start of a new era in its protests against the company. In the past its campaign has targeted the firm's financial backers.

Pharmaceutical companies condemned the attacks, which caused tens of thousands of pounds of damage, and warned that a threat of violence against them was "not conducive to medical research in the UK".

 

Source: The Guardian, February 12

 

Patients challenge animal rights protestors



A patient support group is challenging animal rights activists to refuse any medical treatment developed using results from research carried out on animals. Seriously Ill for Medical Research (SIMR) says that those who oppose such experiments should also refuse the cures. SIMR has produced a card that it says should be carried like an organ donor card by those who oppose the use of animals in medical research. It states that the carrier will refuse all medical treatments developed or tested on animals, which include blood transfusion, anaesthetics, antibiotics and open heart surgery.


Animal rights activists who plan the persecution of people employed in
animal research laboratories will face prosecution following an amendment to
the Criminal Justice and Police Bill, the UK government announced recently. Home Office minister Charles Clarke said the move, which follows 'wholly
unacceptable' attacks on companies such as Huntingdon Life Sciences, was
intended to protect scientists and other research workers.

 

Sources: The Times 15/3/2001 http://www.thetimes.co.uk/article/0,,11-99393,00.htm
The Daily Telegraph 15/3/:
http://www.telegraph.co.uk:80/et?pg=/et/01/3/15/npar15.html#go2

 

Lord's support genetic databases

 

A report published by the House of Lords Science and Technology Committee strongly supports the Medical Research Council and Wellcome Trust proposal for a voluntary UK population database containing the genetic details of 500,000 men and women. To be known as the UK Population Biomedical Collection, the database will also hold other information such as height, weight, medical history and answers to a questionnaire about lifestyle.

 

Source: British Medical Journal 31/3/2001 'House of Lords supports first UK genetic database'
http://www.bmj.com/cgi/content/full/322/7289/755/b

 

British approve therapeutic cloning

 

On January 22, the UK's House of Lords approved (212 in favour, 92 against) a new bill allowing cloning of embryonic stem cells for scientific purposes. With this decision, the UK deviates from an urgent plea of the European Parliament to ban therapeutic cloning.

 

UK'S first frozen egg baby

 

The UK's first IVF baby conceived using a thawed, frozen egg was born
recently. Only around 30 babies worldwide have been conceived using frozen eggs since the technique was introduced 15 years ago. It was developed as an attempt to preserve the fertility of women undergoing chemotherapy treatment for cancer or those at risk of premature menopause. The UK's Human Fertilisation and Embryology Authority (HFEA) lifted its ban on egg freezing last January, but so far only seven British centres have been licensed to carry out the procedure. Although the technique is now licensed for use in the UK, the technique still has quite a low success
rate.

 

Source: BBC News Online:
http://news.bbc.co.uk/hi/english/health/newsid_1215000/1215850.stm

 

UK government to pledge ban on human cloning

 

The UK government has publicly announced its commitment to the introduction of an explicit ban on human reproductive cloning. Whilst an effective ban is already in place, due to the Human Fertilisation and Embryology Authority's promise not to license reproductive cloning, an explicit prohibition has been favoured by the government for some time. Whilst the timing of the legislation remains unclear, its inclusion in Labour's election promises will provide a political imperative.


Source: The Daily Mail 16/4/2001 'Blair's promise to ban human cloning'


Matters of safety in human cloning



In the US, the political battle about human cloning is just about to start. A federal ban on reproductive cloning may be forthcoming - something which President Bush supports.

Lawmakers in the US now say they are considering formally banning human cloning after hearing evidence that the
technology might produce abnormal babies and would be 'reckless and irresponsible' to undertake.
Most scientists consider human cloning at this time to be fraught with dangers for the clones. Not only is animal cloning associated with drastic defects in clones such as respiratory distress, circulatory problems, immune system dysfunction and kidney and brain malformation, but it is also responsible for more subtle long-term genetic changes, probably caused by the nuclear transfer technique which brings about the cloned embryos.
Safety matters enormously - especially for prospective patients - but ultimately it won't win or lose
the political battle. Only an open and honest debate on the rights and wrongs of bringing cloned babies into the world will suffice.

 

Source: New York Times 28/3/2001 'Congressional hearings on human cloning'
http://www.nytimes.com/aponline/science/AP-Human-Cloning.html


 

PPL clones pigs

 


The world's first litter of transgenic cloned pigs has been produced at PPL Therapeutics, the Edinburgh-based biotech company that worked with the Roslin Institute to create Dolly the sheep. The litter of five genetically modified piglets is part of PPL's attempt to advance towards successful transplanting of pig organs into umans. The company now intends to produce transgenic pigs with a different genetic modification in an attempt to prevent potential organ rejection after transplants to humans. It believes that clinical trials could begin within five years.

 

Source: BBC News Online 11/4/2001 'Pig cloning advance'
http://news.bbc.co.uk/hi/english/sci/tech/newsid_1272000/1272655.stm

 

 

Short Research News

 

EMBO meeting for long-term fellows

 

Each year EMBO (the European Molecular Biology Organization - see http://www.embo.org) hosts a meeting for its long term fellows. Around 130 are invited to present their work in talks and poster sessions.

All ACTIP members are invited to the fellows meeting from 24 - 27 June this year at the EMBL, Heidelberg, Germany. This year's programme can be found at:
http://www.embo.org/FM01.html

For more information, contact: Francoise Degrasse
EMBO
Meyerhostrasse 1
D-69117 Heidelberg
francoise.degrasse@embo.org
Fax: +49-6221-8891200

 

 

Stem cell news

 

From skin to heart cell

 

Researchers from PPL Therapeutics, Scotland, have succeeded in turning a cow's skin cell into a heart cell. This breakthrough has significant implications in terms of replacing damaged tissues and organs, but it also allows researchers to move away from the controversial use of human embryo cells.

 

 

Sources: Media release February 23, 2001 http://www.msnbc.com/news/535136.asp

 

Deafness to be treated with stem cells

A scientist at the University of Sheffield believes that stem cell transplants for some deaf people could be attempted within the next three to five years, perhaps allowing them to hear again. Professor Matthew Holley says that transplants of embryonic stem cells in experiments on mice have showed some restoration of auditory function.
It is thought that stem cells might help to repair the nerve and improve the contact between a cochlear implant and the brain.

 

Source:The Independent:
http://www.independent.co.uk/story.jsp?story=62771

 

Stem cells to rebuild heart muscle


Two teams of scientists have made independent breakthroughs using stem cells to repair cardiac muscles damaged by heart attacks. They have shown in experiments on mice that heart muscle can repair after injections of stem cells. The stem cells used in the experiments were derived from the bone marrow of adult mice or taken from human volunteers and have shown the first unequivocal results that adult (rather than embryonic) stem cells are capable of repairing cardiac tissue.
The findings of the studies have surprised the scientists as the evidence was beyond their expectations, showing that the damage caused by heart attacks could be reversed. It is now hoped that clinical trials on human heart attack victims will begin within three years.

 

Source: ScienceDaily magazine 2/4/2001 'Scientists repair damage from heart attack using adult bone marrow stem cells in mice'
http://www.sciencedaily.com/print/2001/04/010402072836.htm

 

 

Fat as a source of stem cells


Researchers, led by Dr Marc Hendrick of the University of California in Los Angeles, have shown that stem cells harvested from human fat can be made to grow into muscle cells in laboratory conditions. The scientists used fat removed during normal liposuction procedures and turned the cells into healthy bone and cartilage cells.
The fact that fat stem cells have been able to be reprogrammed means that an abundant and easy-to-obtain source of such cells might now be available. Previous attempts at using adult stem cells in 'tissue engineering' have been limited by the difficulties in obtaining them from the brain, bone marrow or from fetal tissue.
It is also hoped that fat cells will be an 'ethically neutral' source of stem cells and that the research might transform the way we think about fat.
The potential use of fat cells could make the use of controversial fetal or embryonic stem cells obsolete. It would also have the added benefit of being a genetic match to the person who was treated with stem cells - or, in the
future, tissues cultivated from them - so the problem of tissue transplant rejection may be overcome.

 


Source:
- Science Daily 10/4/2001 'UCLA/Pitt researchers transform human fat into
bone, muscle, cartilage'
http://www.sciencedaily.com/releases/2001/04/010410084918.htm


 

Storing baby's blood for £ 600

For £ 600 parents can protect their new-born by storing blood from the umbilical cord, containing the child's stem cells.

The stem cells will be stored for up to 20 years in liquid nitrogen to provide the child with the potential means to restore damaged organs, blood or tissue.

 

Source: Guardian, February 25, 2001

 

Gene therapy for Alzheimer's disease


Doctors at the University of California, San Diego, have surgically implanted genetically modified cells into the brain of a 60-year old patient suffering from Alzheimer's disease. The therapy is designed to prevent cell loss in the brain. The injection delivered skin cells that had been taken from the patient some months before the brain operation, and which had been modified with nerve growth factor (NGF). The procedure targets the area of the brain that supports memory and cognitive function. It has been shown in studies in primates that this part of the brain responds to NGF.
Critics of the trial say that it is not designed to get to the root of the disease itself and that there are already drugs which achieve a similar result as that intended by the operation.

 

Source: CNN 10/4/2001 'First gene therapy experiment for Alzheimer's'
http://www.cnn.com/2001/HEALTH/conditions/04/10/alzheimer.surgery/index.html

 


Gene News

 

Active genes are strongly clustered

 

Researchers from the Amsterdam Medical Center have constructed a database containing activity of all kinds of genes from healthy and tumour tissue. This transcriptome-map provides new insights into the organisation of the human genome. The researchers found that human chromosomes, contrary to chromosomes of other organisms, show remarkable differences in activity.Chromosomes 13, 18 and 21 show much fewer active genes compared to the others. Gene activity per chromosome is easily depicted in a histogramme. Using the new software, a derailed gene can be located very rapidly.

 

Source: BioNieuws March 3, 2001.

 

Another schizophrenia gene discovered


German scientists at the University of Wurzburg believe that they have found
the gene responsible for an inherited form of schizophrenia. The gene was identified by studying three generations of an extended German family in which many members suffered from catatonic schizophrenia, an uncommon version of the disease which is characterised by extreme physical effects. The gene is found on chromosome 22. The German team thinks that there may be as many as 20 different genes involved in schizophrenia. But other non-genetic factors, such as viral infections during pregnancy, are probably involved.
DeCODE genetics of Iceland has dismissed the German researchers' claim.

 

Source: BioMedNet 20/3/2001 'Division is rife over schizophrenia gene claim'
http://news.bmn.com/news/story?day=010320&story=1

 

 

 

 

Ö.but the risk of older fathers

The risk to a child of developing schizophrenia is thought to rise steadily as the age of the father increases, say researchers at Columbia and New York Universities and the Israeli Ministry of Health. They reviewed
records of nearly 90,000 people born in Jerusalem between 1964 and 1976 and found that men between the ages of 45 and 49 were twice as likely as those under 25 to have children who develop schizophrenia. After the age of 50, the risk was increased threefold.
It is thought that the cause of the problem are sperm cells - passed on to children - which can accumulate mutations as men get older. The researchers believe that this may be the 'tip of the iceberg' in terms of
conditions that may be linked to paternal age.


Source: CNN 13/4/2001 'Study shows male reproductive 'biological clock''
- CNN:
http://www.cnn.com/2001/HEALTH/parenting/04/13/older.fathersreut/index.html




Gene to protect against ovarian cancer?

Scientists at the Queen's University and the Belfast City Hospital believe that they have discovered a gene that protects women against ovarian cancer by regulating the growth and multiplication of cells. The discovery of the gene, which has taken three years, could open up new avenues for diagnosis and treatment of ovarian cancer, which is thought to affect 6,500 women each year in the UK alone.


Your face tells, you're smoking!

Scientists from Guys, Kings and St Thomas' school of medicine believe that chemicals in tobacco may activate a gene that expresses the protein matrix metalloproteinase-1, or MMP-1, in the skin. This breaks down collagen, a protein that maintains elasticity. Too much of this enzyme would increase wrinkling and the ageing effect.

 

Source: The Times 23/3/2001 'Health Warning: smoking does wrinkle the skin'
http://www.thetimes.co.uk/article/0,,72-103915,00.html

 

Early puberty gene discovered

 

Scientists in America have discovered a gene that they believe might double the chances of girls reaching puberty early, thought to be one possible reason for an increased risk of breast cancer. It was reported at the American Association for Cancer Research annual meeting in New Orleans that nearly all girls carrying a specific gene variation experienced puberty as young as nine years old.
The team of scientists found that the gene variant, called CYP1B1, causes testosterone to be broken down twice as rapidly as normal by enzymes in the liver, suggesting that the male sex hormone may be more important in the sexual development of girls than has been thought. Taking part in the study were 192 girls between the ages of nine and 10.

Source: MSNBC 25/3/2001 'Gene may help explain early puberty'
http://www.msnbc.com/news/548914.asp


Do blondes have more fun?



People with blonde hair are being called for a study designed to show whether blondes really do have more fun and why. A team of scientists at Edinburgh University hope to discover why people have different colour hair and how it might affect them. They want blondes of all ages to take part in a two year research project aimed at finding out more about the genetics of their hair colour.
The scientists are trying to find a gene that gives some people blonde colouring in order to see what advantages having that gene might bring, especially when it is known that having blonde hair seems to make people more prone to sunburn and skin cancer. Earlier work done by the team on red haired people seemed to suggest that no evolutionary selection was at work, but that the gene code for red was just 'genetic drift'.

 

Source: BBC News Online 28/3/2001 'What is it about blondes?'
http://news.bbc.co.uk/hi/english/education/newsid_1248000/1248103.stm

 


 

On the web

 

 

Contribute to protein folding with your screensaver

Inspired by the success of Seti@home, the screensaver that contributes to searching among billions of signals for extraterrestial life, Prof. Vijay Pande of Stanford University has developed Folding@home, a screensaver that contributes to calculations of protein folding. The screensaver shows the proteins that are being folded. Unfortunately, the screensaver only works on PCs that have a direct connection to Internet. Via the website of folding@home progress of the project can be followed. The programme can be downloaded from:

 

www.foldingathome.stanford.edu

 

 

Quality of Life Bulletin only on web

DG Research used to send us the Quality of Life Bulletin, but as of recently it is only available via the web. Visit:

 

www.cordis.lu/life

 

 

All about genetic research

If you do not want to miss anything concerning genes and genome research, visit the freely available GeneLetter, full of interesting articles and easy to navigate links:

 

www.geneletter.com

 

 

 

Key info on ethics

 

The European Commission has launched a website that guides researchers towards the most important reference texts in the area of ethics in research:

 

http://www.cordis.lu/science-society

 

 

 

Latest on BSE

 

A very useful site chockfull of links and latest information about BSE, called LinksDossier. Very comprehensive!:

 

http://www.euractiv.com/dossiers/ld_bse.htm

 

 

 

Harmonization

Regularly, the Council of Europe's EDQM publishes proceedings of conferences dealing with harmonised regulatory frameworks. Keep checking their website for the most recent ones, such as one called 'current developments in pharmaceutical analysis':

http://www.pheur.org

 

 

Partners for Life

Partners for Life is a new EU project that provides economic and technological intelligence to SMEs. The aim is to offer targeted information on technological and market trends in the field of life sciences and to support their participation in European research projects, in particular in biomedicine, biotechnology and agro-industry. Groups of SMEs preparing innovative projects can receive up to 1 million EURO for research. Submission of joint projects is possible until April 2002.

 

www.bit.ac.at/partners_for_life.htm

 

Funding

Information about funding opportunities in Europe can be found at:

www.welcomeeurope.com

 

 

Publications

 

 

Nature Genome Exclusive

 

Individual subscribers to one of the many Nature publications received from the publisher a commemorative copy of The Human Genome. Beautifully printed, but if you didn't receive one: the entire content plus additional features and commentary is available without restriction on:

 

www.nature.com/genomics

 

The facts about the human genome:

 

  1. the human genome contains 2.91 billion base pairs;
  2. 1.1% of DNA codes for proteins;
  3. 24% of DNA is located in introns;
  4. 75% of DNA is junk;
  5. there are 2.1 million SNPs, and fewer than 1% influences proteins;
  6. 26,383 genes have been identified, and 42% has an unknown function;
  7. another 12,731 candidate genes have been identified;
  8. average size of genes is 28,000 base pairs;
  9. chromosome 19 has more than 1,400 genes (23 genes per million base pairs), but chromosome 13 has only 13 genes per million base pairs;
  10. 35% of the genome contains repeating sequences;
  11. humans share 2,758 genes with Drosophila, 2,031 with Caenorhabdus, and 223 exclusively with bacteria;
  12. on average a gene produces 3 different proteins;

 

Source: BioNieuws, March 3, 2001

 

 

The surprises of the human genome

 

 

The human genome has produced a number of surprises. Here are 10:

  1. The genome is like a wasteland with scattered cities: large 'deserts' of million base pairs in which nothing is happening alternate with clusters of active genes;
  2. We only have approx. 31,000 genes, instead of the expected 100,000
  3. because of exons, human genes can make three times as much protein per gene as the genes of a simple organism;
  4. Most human proteins are much more comples than the proteins of simpler organism, containing several active domains;
  5. More than 200 human genes are the result of horizontal bacterial gene transfer. These genes are not found in Drosophila, worms or yeast;
  6. Approximately half of human DNA consists of repeating sequences, forming an 800 million year old archive;
  7. Selfish junk DNA can be a nuisance, as the sequence Alu (200-300 bases) occurs more than one million times in the genome;
  8. Mutation frequency in men is twice as high as the mutation frequency in women;
  9. There is no scientific basis for racial differences, since all human beings are 99,9% equal to each other with respect to their DNA;

(10) The genome already offers advantages in terms of discovery of disease-associated genes (see also our 'Short Research News'.

 

 

 

New Ernst & Young publication: convergence

Convergence between research, finance and public opinion is positioning biotechnology to become the most dynamic industry of the 21st century, according to Ernst&Young's Biotechnology Report, Millenium Edition: Convergence. The report cites advances in genomics as a driving force behind investment, spurring activity. The report notes that convergence in several areas, including information technology, health care and various industial sectors, coupled with new business models, has the potential to revolutionize the biotechnology industry.

 

Copies from Ernst & Young, 50 $ each, or read the Executive Summary online at www.ey.com

 

Proposal FP 6

 

 

Goal: to implement European Research Area

 

Recently, the European Commission presented its proposal for a "multiannual Framework Programme 2002-2006 of the European Community for Research, Technological Development and demonstration activities aimed at contributing towards the creation of the European Research Area". In short, a proposal for a 6th Framework Programme (FP 6). As the title shows, FP6 is meant to implement the European Research Area. It is designed to:

(1) step up its (ERAs) contribution to the development of scientific and technical excellence in Europe, in EU countries and non-EU countries, both in universities and in industry.

(2) increase its impact on the innovation process in Europe;

(3) reinforce its contribution to the efforts to integrate European Research.

 

 

Maximum budget proposed is 16.270 million EURO.

 

Various institutions will be consulted regarding this proposal. Proposals for specific programmes will follow later. It is the intention that the Council and the European Parliament will adopt FP 6 not later than the first half of 2002.

 

Why the European Research Area?

 

The European Research Area (ERA) has become the reference framework for research policy issues in Europe. It is seen as a central component to promote innovation, competitiveness and employment, sustainable economic growth and social cohesion in Europe.

 

The necessity of ERA is evidenced by:

(1) the EU's major technological rivals are stepping up their efforts (US public spending on research will grow by 9% in 2001);

(2) prospects in life sciences and technologies are promising; the challenge is to capitalize on the human genome;

(3) there is a growing role for information and communication sciences;

(4) science holds to a large extent the key to solving societal problems (i.e. BSE);

(5) sustainable development is a major political objective on the EU agenda.

 

Principle of Framework Programme 6

 

The new FP will be based on the following main principles:

I. concentrating on a selected number of priority research areas in which EU action can add the greatest possible value;

II. defining the various activities in such a way as to enable them to exert a more structuring effect on the research activities conducted in Europe thanks to a stronger link with national, regional and other European initiatives;

III. simplifying and streamlining the implementation arrangements, on the basis of the intervention methods defined and the centralised management procedures envisaged: networks of excellence and integrated projects will be administered to a large extent autonomously by participants: to involve other partners, define small-scale projects, adapt their programme of research to meet changing needs. Certain aspects of the specific research activities and support for researcher mobility will be entrusted to external organisations operating under the Commission's responsibility.

 

Special efforts:

A special effort will be made to maximise the dissemination of results and to express them in terms that are readily understandable to decision makers, so as to help them implement public policies.

Another special effort will be made to increase the participation of women in all activities of the programme.

All research activities carried out under the FP 6 must be carried out in compliance with fundamental ethical principles.

Two fundamental new aspects are (1) the full participation of candidate countries and (2) the opening up of EU research activities to the rest of the world.The regional dimension of European research will be fully taken into account.

 

 

 

Concentrating (focusing) efforts

 

To ensure the focusing of efforts, FP6 will be integrated around three targets:

1. Integrating European research;

2. Structuring the European Research Area;

3. Strengthening the foundations of the European Research Area.

 

 

 

Target 1.

Integrating European Research

(12.770 million EURO)

 

The bulk of FP6 efforts are intended to strengthen the scientific and technological bases of Community industry. These activities will be carried out:

 

1. In a limited number of priority areas by means of networks of excellence, integrated projects and EU participation in national research programmes. Participation of SMEs in networks of excellence and integrated projects should be significant. Two new instruments will be introduced: a collective research scheme and extension of 'cooperative research activities'. International cooperation will be important.

2. In areas related to the anticipation of EU science and technology needs (help to anticipate emerging needs, react rapidly to new scientific and technological developments and be present at the frontiers of knowledge (annual decisions following calls for proposals, choice of topics by the Commission)

3. In the field of science and technology as a whole in the case of complementary research activities for SMEs.

As a fundamental general principle, competitive calls for proposals and evaluation by means of peer review will be used to implement the bulk of the activities.

Instruments to integrate research are:

a. Networks of excellence, characterised by a joint programme of activities, precise research themes and topics, and activities to manage, transfer and exploit the knowledge produced. Selection will be on the basis of calls for proposals. A network of excellence will involve several million EURO.

b. Integrated projects will involve consortia with intense university/industry collaboration. They should concern risky research and have clearly defined objectives. Participation will be through calls for proposals. Max support will be 50% of the proposed budget. A project may involve tens of millions of EUROs.

c. Participation in national programmes. The EU may contribute to national programmes. Max support will be 50% of the proposed budget. This new element will require a lot of consultation.

 

1.1. Priority thematic areas of research

Seven thematic areas have been selected. These have, within each of them, a number of subjects linked to economic and societal issues that are especially important to the EU and where its action adds specific value for reasons which may vary according to the themes in question. Some activities, particularly those intended to help structure the European Research Area, will be opened up to all themes and areas.

Activities are intended to assemble a critical mass of resources and support a high level of integration of research capacities in Europe in areas in which this is especially necessary for the competitiveness of European industry or the major political and social implications of the issues in question. The seven priority thematic areas are:

1. Genomics and biotechnology for health (2 000 million EURO);

2. Information Society Technologies (3,600 million EURO);

3. Nanotechnologies, intelligent materials and new production processes (1,300 million EURO);

4. Aeronautics and space (1,000 million EURO);

5. Food safety and health risks (600 million EURO);

6. Sustainable development and global change (1,700 million EURO);

7. Citizens and governance in the European knowledge-based society (225 million EURO);

 

Genomics and biotechnology for health

 

With respect to genomics and biotechnology for health, the objectives are to help Europe exploit, by means of an integrated research effort, breakthroughs achieved in decoding the genomes of living organisms, Ö.for the benefit of public health and citizens and to increase the competitiveness of the European biotechnology industry.

Community activities will address the following aspects:

1. fundamental knowledge and basic tools for functional genomics: gene expression and proteomics; structural genomics; comparative genomics and population genetics; bioinformatics;

2. application of knowledge and technologies in the field of genomics and biotechnology for health: technological platforms for the development of new diagnostic, prevention and therapeutic tools; support for innovative research in genomics start-up companies;

3. application of medical genomics knowledge and technologies in the following fields: combating cancer, degenerative diseases of the nervous system, cardiovascular diseases and rare diseases; combating resistance to drugs; studying human development, the brains and the ageing process.

A broader approach will be pursued with regard to combating the three poverty-linked infectious diseases (AIDS, malaria and tuberculosis), which have priority in terms of disease control at EU and international level.

 

Other themes of interest

Other priority themes with topics of interest are:

 

Nanotechnologies, which aim to achieve a critical mass of capacities needed to develop and exploit, especially for greater eco-efficiency, leading-edge technologies for the knowledge and intelligence-based products, services and manufacturing processes of the years to come.

Actions envisaged include applications of nanobiotechnologies in areas such as health, chemistry, energy, optics and the environment.

 

Food safety and health risks include, among others, methods of analysis and detection of chemical contaminants and pathogenic microorganisms (incl. prions)

The final theme, citizens and governance, includes such a wide variety of topics as improving the production, transmission and utilisation of knowledge in Europe; transnational research and comparative studies; interdisciplinary research in support of public policies; and the establishment and exploitation on a European scale of research infrastructures and data and knowledge bases.

 

1.2. Anticipating the EUs scientific and technological needs (2,345 million EURO)

Objective: respond to the scientific and technological needs of the policies of the Community;

Respond more flexibly and rapidly to emerging scientific and technological needs and major unforeseeable developments, as well as needs appearing at the frontiers of knowledge.

The activities will address the following themes:

 

1. Activities carried out on the basis of calls for proposals

a. In particular research in support of common policies, EU objectives

b. Research that responds to needs in new areas at the leading edge of knowledge.

Activities will essentially take the form of:

1. Specific targeted projects generally of a limited scale;

2. The networking of research activities carried out at national level

The choice of research topics will be made by the Commission on the basis of assessment by an internal group of users

These activities will also comprise, in particular, specific research activities for SMEs:

(i). Collective research activities (by technical research centres of industrial associations or industry groupings in entire sectors of industry dominated by SMEs at the European level;

(ii). Cooperative research activities by research centres for a number of SMEs on themes of common interest

 

2. Joint Research Centre Activities

 

 

Target 2.

Structuring the European Research Area (3,050 million EURO)

 

 

a. Research and innovation: stepping up economic and technological intelligence activities, utilisation of research results, transfer of knowledge, setting up of technology businesses in Europe. (300 million EURO)

b. Human resources and mobility. More funding, making Europe more attractive to third-country researchers, and support schemes for excellent EU research teams. (1,800 million EURO)

c. Research infrastructures of the highest level in Europe and promote their optimal use on a European scale. Broadband communication infrastructures, transnational access, networking. (900 million EURO)

d. Science/society: activities to encourage harmonious relations between science and society and the opening up of innovation in Europe as a result of the establishment on new relations and an informed dialogue between researchers, industrialists, political decision makers and citizens (50 million EURO)

 

Target 3.

Strengthening the foundations of the European Research Area (450 million EURO)

 

The activities are intended to step up the coordination and support the coherent development of research and innovation-stimulation policies and activities in Europe. The activities will take the following form:

a. Strengthening coordination of research: mutual opening up of research programmes, networking of research activities conducted at national level, scientific and technological cooperation activities, collaboration and joint initiatives of CERN, EMBL, ESO and ESA;

b. Supporting the development of coherent research and innovation policies: analyses and studies, specialised working groups, forums for concertation and political debate, benchmarking of research and innovation policies, mapping of scientific and technological excellence.

 

References:

 

The full text of the proposal can be downloaded from the CORDIS website (http://www.cordis.lu) or you can request a copy from the IVTIP Secretariat.

Reference: COM (2001) 94 final, Brussels, 21.2.2001 for explanatory memorandum, reference 2001/0053 (COD) for RTD proposal itself.

 

 

AGENDA

 

A number of interesting conferences and workshops is coming up. Of all the events mentioned here, the detailed programmes and registration/application forms are available from the ACTIP secretariat.

 

.

 

Industrial & Intellectual Property Conference

May 10-11, 2001, Brussels

Organization: Competence Promotion Center. Tel + 32 2 237 09 00; fax: + 32 2 230 46 49. www.competence.ibf.be

 

GMP compliance in Europe

May 10-11, 2001, Brussels

Organization: EDQM, fax: + 33 388 41 27 71; tel: + 33 388 41 28 15. Web: www.pheur.org

 

 

10th International Congress for Human genetics

May 15-19, 2001, Vienna, Austria

Organization: HYPERLINK mailto:jderoos@rose-international.com jderoos@rose-international.com

 

Impact of genomics on Medicine

May 21-22, 2001, Munich, Germany

Organisation: Cambridge HealthTech Institute, email: chi@healthtech.com or www.healthtech.com

 

Early drug target validation

May 21-22, 2001 Geneva, Switzerland

Organization: Vision in Business Ltd. Tel + 44 20 7256 5188

 

 

Technology Commercialisation: Developing Biotech Start-ups

May 23, 2001, London UK

Organization: SMI Pharmaceutical Conferences. Tel + 44 207 252 22 22

 

From genes to drugs: innovations in cardiovascular therapeutics

May 23-24, San Diego

Organization: SMI Pharmaceutical Conferences. www.smi-online.co.uk/genes.asp

 

 

 

Biologic 2001

Delivering integrated scale-up and manufacturing solutions

June 4-6, Geneva, Switzerland

Organization: ECPI: HYPERLINK http://www.ecpi-online.com www.ecpi-online.com, or Nicola McCall on +44 20 7827 5965

 

8th International Inhalation Symposium

Drug research and clinical inhalation

June 6-9, 2001 Hannover Germany

Organization: fraunhofer Institute of Toxicology. www.ita.fhg.de. Tel + 49 511/53 50 121

 

17th ESACT meeting

From target to market

 

June 10-14, 2001, Tylösand, Sweden

Organization: ESACT Secretariat, fax + 46 8 730 06 99; email: www.esact.org

 

Protein Biotechnology in the 21st Century

June 11-15, 2001, Amersfoort, The Netherlands

Organization: Dutch Royal Society of Chemistry: www.bloup.com

 

 

 

EMBO long-term fellows meeting

24 - 27 June, EMBL, Heidelberg, Germany.

Organization: EMBO, Francoise Degrasse, Heidelberg
francoise.degrasse@embo.org
Fax: +49-6221-8891200

Programme at: http://www.embo.org/FM01.html

 

BIO's International Convention and Exhibition

June 24-27, 2001, San Diego, California

Organization: BIO. www.bio.org or Tel + 1 202 857 02 44

10th European Congress on Biotechnology (ECB 10)

July 8-11, 2001, Madrid, Spain</P>

Organization: EFB, Dechema

 

43rd International Meeting of the European Tissue Culture Society

5th Gene Delivery & Cellular Protein Expression Conference

September 9-13, 2001, Vienna, Austria

Organization: Reingard Grabherr, University of Agriculture, Austria. Email: HYPERLINK mailto:r.grabherr@iam.boku.ac.at r.grabherr@iam.boku.ac.at

 

ACTIP annual plenary meeting

September 20-21, York, UK

Organization: ACTIP Secretariat: www.ACTIP.org

 

15th Forum for Applied Biotechnology

Sept 24-25, 2001, Gent, Belgium

Organization: GOM-West-Vlaanderen; tel + 32 50 36 71 31; fax; + 32 50 36 31 86

 

 

Cell Interactions and Cellular Complexity

Sept 30-October 3, 2001, Granada, Spain

Organization: European Tissue Culture Society. web: www.san.gva.es/centros/lafe/ETCS/ETCS_ESP-granada-2001-00.html

 

Vaccines of the future: from rational design to clinical development

October 17-19, 2001, Paris France

Organization: Institut Pasteur Euroconferences. Fax: + 33 1 40 61 34 05. www.pasteur.fr/applications/euroconf

 

Genome 2001-05-02

22-24 October 2001, London

Organization: ECPI. Fax: + 44 20 7242 1508

 

Second European Meeting on Cell Engineering

October 26-28, 2001, Costa Brava, Spain</P>

Organization: Dr. Mohammed Al-Rubai, Dr. David lLoyd: email: D.R.Lloyd@bham.ac.uk; http://www.bham.ac.uk/ChemEng/actg/ewce2.htm

 

9th meeting of the European Society of Gene Therapy

November 2-4, 2001, Antalya, Turkey

Organization: Congrex Sweden AB, email esgt@congrex.se, or the congress manager, email: binanc@serenas.com.tr

 

Pharmaceutical products and viral safety

March 14-15, 2002, Paris France

Organization: Institut Pasteur Euroconferences. Fax: + 33 1 40 61 34 05. www.pasteur.fr/applications/euroconf

 

 

 

 


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