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In this
issue:
Summary
proposal FP 6
Recently, the European Commission
presented its proposal for a next Framework Programme (FP 6).
In this issue of the ACTIP Bulletin we review this proposal,
both with respect to the background as with the proposed content.
The article starts on page15, but first we review other, equally
important news:
Deadlines for FP5 proposals;
Commission adopts Communication
on precautionary principle;
New vaccine projects;
ACTIP website popular
During the month of March, the
ACTIP website proved a success, with 23,769 requests and
a total of 4,636 visits.
The number of unique visitors
was1,026, and the repeat visitors numbered 370, visiting the
site 2-4 times (202), 5-9 times (33), 10-24 times (78) and 25-49
times (57). This indicates that many people are using the website
as a gateway site and a source of valuable documentation.
The majority of visitors is commercial
and from the USA, followed by visitors from Japan, US educational
institutions, Mexico, the UK, Denmark, Germany etc.
In the month of March, the most
frequently visited page was the links page and the one with our
latest position paper, followed by the members page, the news
page and the secure page. With 59 hits the secure page (only
for ACTIP members) is well visited. The various monographs average
30-40 visits per month.
Europe and Biotechnology
In February, the European
Parliament (EP) appproved the revised 'deliberate release'
directive 90/220 EC. This should have opened the way to approval
of requests for marketing authorization of GMO plants.
However, the decision by six
member states (France, Denmark, Italy, Greece, Austria and Luxembourg)
to maintain an unoffical ban on GMO food leaves plant biotech
companies at a crossroads. They pledged to maintain the ban "until
effective arrangements are adopted for the traceability and labelling
of GMOs". This way, the de facto moratorium, which seemed
at the end of its days once the revised directive 90/220 was
adopted, could be prolonged by years, leaving the plant biotechnology
industry at a serious disadvantage. Some product applications
are already in the regulatory pipeline since 1997.
Source: European Voice, March
21, 2001-04-24
On a more positive note ended
a meeting of the European Council on March 23-24, 2001 during
the Stockholm summit. The European Council confirmed that it
consideres a competitive biotechnology-based industry as a key
requirement and asset for Europe in the 21st century.
The heads of government explicitly recognized the need for measures
to utilize the full potential of biotechnology and to strengthen
the competitiveness of the biotechnology-based industry.
Source: Press release EuropaBio,
March 26, 2001
A similar message was supported
by a large majority of the European Parliament when it approved
the report of MEP John Purvis about the future of the Biotechnology
Industry on March 12. The report criticises the de facto moratorium
and calls upon the future European Food Safety Authority to restore
consumer confidence in GM Foods.
Source: European Parliament
Daily Notebook, March 15, 2001
News from the Commission
Deadlines
for FP5 proposals
First half 2001
In the first few months of the
year 2001, 6 deadlines for proposals had been scheduled. The
following had been submitted:
- * 110 for Accompanying Measures;
* 48 for Socio-Economic/Bioethical studies
* 21 for Research Infrastructures
* 96 for Marie Curie Training
Host Sites (of which 60 in industry)
* 128 for SME measures (74 Exploratory
Awards and 54 CRAFT).
In addition, 71 expression of
interest for topics in functional genomics relating to human
health were received.
Second half 2001
The following programmes are
open for proposals:
Accompanying measures: deadlines
June 12, 2001 and October 11, 2001
Marie Curie Individual Fellowships:
deadlines October 10, 2001
SME Cooperative Research Awards:
deadline September 19, 2001
Mechanism for the submission
of joint projects under the 'Partner for Life': available until
April 2002. Intended for SMEs, to support their participation
in European Research Projects. See also:
www.bit.ac.at/partners_for_life.htm
Commission
adopts communication on Precautionary Principle
On February 2, 2000, the European
Commision has adopted a Communication on the Use of the Precautionary
Principle.
The Communication underlines
that the precautionary principle forms part of a structured approach
to the analysis of risk, as well as being relevant to risk management.
It covers cases where scientific evidence is insufficient, inconclusive
or uncertain and preliminary scientific evaluation indicates
that there are reasonable grounds for concern that the potentially
dangerous effects on the environment, human, animal or plant
health may be inconsistent with the high level of protection
chosen by the EU.
The Communication makes it clear
that the precautionary principle is neither a politicisation
of science or the acceptance of zero-risk but that it provides
a basis for actiob when science is unable to give a clear answer.
A copy of the press release
and the Communication itself is available on request from the
IVTIP Secretariat.
New
vaccine projects
Since September last year, a
number of new vaccine projects have been started in Key Action
2, Control of Infectious Diseases. Below we give the titles and
the project's number. If you want to obtain an abstract of the
project, you can do two things: either visit
http://dbs.cordis.lu/EN_PROJI_search.html,
and type in as keywords the project's
number, or, if you want to see all projects supported under KA2,
type in QLK2 and you get a complete listing. Alternatively, ask
the ACTIP secretariat for a copy or file of the abstracts listed
below.
- Adhesive interactions in malaria:
new targets for intervention. QLK2- 2000-00109
- New tools to investigate and
suppress HIV drug resistance. QLK2-2000-00291
- Development and evaluation of
nucleic acid amplification methods for the detection of respiratory
pathogens in community acquired pneumonia. QLK2-2000-00294
- Immunological mechanisms of
T-cell activation by dendritic cells: a novel strategy for immune
intervention. QLK2-2000-00470
- Immunotherapy of enteric infections
by rotaviruses and coronaviruses using plantibodies. QLK2-2000-00739
- Development and testing of a
combined antiretroviral, immune and gene therapy for treatment
of HIV patients. QLK2-2000-01040
- Combined immune and gene therapy
for chronic hepatitis. QLK2-2000-01476
Business
News
Changes
to EU patent system
On November 29, 2000,
agreement was reached on a number of important amendments to
the European Patent Convention. All are expected to enter into
force within the next four years.
The amendments to the
EPC relate primarily to the streamlining of granting procedure,
in particular the language system:
- once effective, applicants
will be able to file a patent application in any of the languages
of the designated countries and, if this is not one of the three
official EPC languages (English, German and French), a translation
into one of these need only take place at a later stage. This
will reduce costs by some 50%
- In the grant procedure,
search (novelty) and examination (inventiveness) will be combined,
with one examiner in principle carrying out both;
- computer programmes
remain unpatentable, but computer-implemented inventions can
be patented if they involve a new and inventive technical contribution
to the state of the art.
Celera
and rivals in rat genome project
Celera Genomics will
share a new 58 million USD grant with the Baylor College of Medicine,
which was one of the five sequencing centers for the Human Genome
Project. Baylor and Celera did not decide to cooperate on their
own. Each applied to win the full grant, which the NIH decided
to split, with about 60% going to Baylor. Dr. Venter said cooperating
with government was a cost-effective way to add to its database
of genetic information. Other participants in the rat project
are Genome Therapeutics Corp. of Waltham, Mass., the Institute
for Genomic Research in Rockville, Md and the University of British
Columbia.
Source: New York
Times, March 1, 2001
Drug
firm's alarm over costly delays
A European Commission
funded study has found that many pharmaceutical firms complain
how the EU-wide system for drug approval and the EMEA has worked
in practice, featuring many costly delays. Companies are also
alarmed over the way many member states continue to ignore the
alternative system, insisting that drugs accepted elsewhere still
run the bureaucratic gauntlet of domestic authorisation procedures.
The competent authorities do not seek to disguise the fact that
there is unwillingness of member states to abide by the principles
of mutual recognition, states the report.
Source: European
Voice, January 10, 2001
Pharmaceutical
firms attacked
On February 11 last,
animal rights activists in the UK mounted demonstrations against
pharmaceutical companies which they claimed support testing of
drugs on animals at Huntingdon Life Sciences.
Hundreds of protesters
were involved in a coordinated series of break-ins or demonstrations
at the laboratories, offices and at the homes of directors of
five leading companies: Bayer, Eli Lilly, Novartis Pharmaceuticals,
Roche and Pharmacia Corporation.
The protestors hope
to persuade the companies to withdraw their support from Huntingdon's
laboratories in Cambridgeshire and in Occold, Suffolk. They said
the demonstrations marked the start of a new era in its protests
against the company. In the past its campaign has targeted the
firm's financial backers.
Pharmaceutical companies
condemned the attacks, which caused tens of thousands of pounds
of damage, and warned that a threat of violence against them
was "not conducive to medical research in the UK".
Source: The Guardian,
February 12
Patients
challenge animal rights protestors
A patient support
group is challenging animal rights activists to refuse any medical
treatment developed using results from research carried out on
animals. Seriously Ill for Medical Research (SIMR) says that
those who oppose such experiments should also refuse the cures.
SIMR has produced a card that it says should be carried like
an organ donor card by those who oppose the use of animals in
medical research. It states that the carrier will refuse all
medical treatments developed or tested on animals, which include
blood transfusion, anaesthetics, antibiotics and open heart surgery.
Animal rights activists who plan the persecution of people employed
in
animal research laboratories will face prosecution following
an amendment to
the Criminal Justice and Police Bill, the UK government announced
recently. Home Office minister Charles Clarke said the move,
which follows 'wholly
unacceptable' attacks on companies such as Huntingdon Life Sciences,
was
intended to protect scientists and other research workers.
Sources: The Times
15/3/2001 http://www.thetimes.co.uk/article/0,,11-99393,00.htm
The Daily Telegraph 15/3/: http://www.telegraph.co.uk:80/et?pg=/et/01/3/15/npar15.html#go2
Lord's
support genetic databases
A report published
by the House of Lords Science and Technology Committee strongly
supports the Medical Research Council and Wellcome Trust proposal
for a voluntary UK population database containing the genetic
details of 500,000 men and women. To be known as the UK Population
Biomedical Collection, the database will also hold other information
such as height, weight, medical history and answers to a questionnaire
about lifestyle.
Source: British
Medical Journal 31/3/2001 'House of Lords supports first UK genetic
database'
http://www.bmj.com/cgi/content/full/322/7289/755/b
British
approve therapeutic cloning
On January 22, the
UK's House of Lords approved (212 in favour, 92 against) a new
bill allowing cloning of embryonic stem cells for scientific
purposes. With this decision, the UK deviates from an urgent
plea of the European Parliament to ban therapeutic cloning.
UK'S
first frozen egg baby
The UK's first IVF
baby conceived using a thawed, frozen egg was born
recently. Only around 30 babies worldwide have been conceived
using frozen eggs since the technique was introduced 15 years
ago. It was developed as an attempt to preserve the fertility
of women undergoing chemotherapy treatment for cancer or those
at risk of premature menopause. The UK's Human Fertilisation
and Embryology Authority (HFEA) lifted its ban on egg freezing
last January, but so far only seven British centres have been
licensed to carry out the procedure. Although the technique is
now licensed for use in the UK, the technique still has quite
a low success
rate.
Source: BBC News
Online:
http://news.bbc.co.uk/hi/english/health/newsid_1215000/1215850.stm
UK
government to pledge ban on human cloning
The UK government has
publicly announced its commitment to the introduction of an explicit
ban on human reproductive cloning. Whilst an effective ban is
already in place, due to the Human Fertilisation and Embryology
Authority's promise not to license reproductive cloning, an explicit
prohibition has been favoured by the government for some time.
Whilst the timing of the legislation remains unclear, its inclusion
in Labour's election promises will provide a political imperative.
Source: The Daily Mail 16/4/2001 'Blair's promise to ban human
cloning'
Matters
of safety in human cloning
In the US, the
political battle about human cloning is just about to start.
A federal ban on reproductive cloning may be forthcoming - something
which President Bush supports.
Lawmakers in the US
now say they are considering formally banning human cloning after
hearing evidence that the
technology might produce abnormal babies and would be 'reckless
and irresponsible' to undertake.
Most scientists consider human cloning at this time to be fraught
with dangers for the clones. Not only is animal cloning associated
with drastic defects in clones such as respiratory distress,
circulatory problems, immune system dysfunction and kidney and
brain malformation, but it is also responsible for more subtle
long-term genetic changes, probably caused by the nuclear transfer
technique which brings about the cloned embryos.
Safety matters enormously - especially for prospective patients
- but ultimately it won't win or lose
the political battle. Only an open and honest debate on the rights
and wrongs of bringing cloned babies into the world will suffice.
Source: New York
Times 28/3/2001 'Congressional hearings on human cloning'
http://www.nytimes.com/aponline/science/AP-Human-Cloning.html
PPL
clones pigs
The world's first
litter of transgenic cloned pigs has been produced at PPL Therapeutics,
the Edinburgh-based biotech company that worked with the Roslin
Institute to create Dolly the sheep. The litter of five genetically
modified piglets is part of PPL's attempt to advance towards
successful transplanting of pig organs into umans. The company
now intends to produce transgenic pigs with a different genetic
modification in an attempt to prevent potential organ rejection
after transplants to humans. It believes that clinical trials
could begin within five years.
Source: BBC News
Online 11/4/2001 'Pig cloning advance'
http://news.bbc.co.uk/hi/english/sci/tech/newsid_1272000/1272655.stm
Short Research News
EMBO
meeting for long-term fellows
Each year EMBO (the
European Molecular Biology Organization - see http://www.embo.org) hosts a meeting for its long
term fellows. Around 130 are invited to present their work in
talks and poster sessions.
All ACTIP members are invited to the fellows meeting from 24
- 27 June this year at the EMBL, Heidelberg, Germany. This year's
programme can be found at: http://www.embo.org/FM01.html
For more information, contact: Francoise Degrasse
EMBO
Meyerhostrasse 1
D-69117 Heidelberg
francoise.degrasse@embo.org
Fax: +49-6221-8891200
Stem
cell news
From
skin to heart cell
Researchers from PPL
Therapeutics, Scotland, have succeeded in turning a cow's skin
cell into a heart cell. This breakthrough has significant implications
in terms of replacing damaged tissues and organs, but it also
allows researchers to move away from the controversial use of
human embryo cells.
Sources: Media release
February 23, 2001 http://www.msnbc.com/news/535136.asp
Deafness
to be treated with stem cells
A scientist at the
University of Sheffield believes that stem cell transplants for
some deaf people could be attempted within the next three to
five years, perhaps allowing them to hear again. Professor Matthew
Holley says that transplants of embryonic stem cells in experiments
on mice have showed some restoration of auditory function.
It is thought that stem cells might help to repair the nerve
and improve the contact between a cochlear implant and the brain.
Source:The Independent:
http://www.independent.co.uk/story.jsp?story=62771
Stem
cells to rebuild heart muscle
Two teams of scientists
have made independent breakthroughs using stem cells to repair
cardiac muscles damaged by heart attacks. They have shown in
experiments on mice that heart muscle can repair after injections
of stem cells. The stem cells used in the experiments were derived
from the bone marrow of adult mice or taken from human volunteers
and have shown the first unequivocal results that adult (rather
than embryonic) stem cells are capable of repairing cardiac tissue.
The findings of the studies have surprised the scientists as
the evidence was beyond their expectations, showing that the
damage caused by heart attacks could be reversed. It is now hoped
that clinical trials on human heart attack victims will begin
within three years.
Source: ScienceDaily
magazine 2/4/2001 'Scientists repair damage from heart attack
using adult bone marrow stem cells in mice'
http://www.sciencedaily.com/print/2001/04/010402072836.htm
Fat
as a source of stem cells
Researchers, led
by Dr Marc Hendrick of the University of California in Los Angeles,
have shown that stem cells harvested from human fat can be made
to grow into muscle cells in laboratory conditions. The scientists
used fat removed during normal liposuction procedures and turned
the cells into healthy bone and cartilage cells.
The fact that fat stem cells have been able to be reprogrammed
means that an abundant and easy-to-obtain source of such cells
might now be available. Previous attempts at using adult stem
cells in 'tissue engineering' have been limited by the difficulties
in obtaining them from the brain, bone marrow or from fetal tissue.
It is also hoped that fat cells will be an 'ethically neutral'
source of stem cells and that the research might transform the
way we think about fat.
The potential use of fat cells could make the use of controversial
fetal or embryonic stem cells obsolete. It would also have the
added benefit of being a genetic match to the person who was
treated with stem cells - or, in the
future, tissues cultivated from them - so the problem of tissue
transplant rejection may be overcome.
Source:
- Science Daily 10/4/2001 'UCLA/Pitt researchers transform human
fat into
bone, muscle, cartilage'
http://www.sciencedaily.com/releases/2001/04/010410084918.htm
Storing
baby's blood for £ 600
For £ 600 parents
can protect their new-born by storing blood from the umbilical
cord, containing the child's stem cells.
The stem cells will
be stored for up to 20 years in liquid nitrogen to provide the
child with the potential means to restore damaged organs, blood
or tissue.
Source: Guardian,
February 25, 2001
Gene
therapy for Alzheimer's disease
Doctors at the
University of California, San Diego, have surgically implanted
genetically modified cells into the brain of a 60-year old patient
suffering from Alzheimer's disease. The therapy is designed to
prevent cell loss in the brain. The injection delivered skin
cells that had been taken from the patient some months before
the brain operation, and which had been modified with nerve growth
factor (NGF). The procedure targets the area of the brain that
supports memory and cognitive function. It has been shown in
studies in primates that this part of the brain responds to NGF.
Critics of the trial say that it is not designed to get to the
root of the disease itself and that there are already drugs which
achieve a similar result as that intended by the operation.
Source: CNN 10/4/2001
'First gene therapy experiment for Alzheimer's'
http://www.cnn.com/2001/HEALTH/conditions/04/10/alzheimer.surgery/index.html
Gene
News
Active
genes are strongly clustered
Researchers from
the Amsterdam Medical Center have constructed a database containing
activity of all kinds of genes from healthy and tumour tissue.
This transcriptome-map provides new insights into the organisation
of the human genome. The researchers found that human chromosomes,
contrary to chromosomes of other organisms, show remarkable differences
in activity.Chromosomes 13, 18 and 21 show much fewer active
genes compared to the others. Gene activity per chromosome is
easily depicted in a histogramme. Using the new software, a derailed
gene can be located very rapidly.
Source: BioNieuws
March 3, 2001.
Another
schizophrenia gene discovered
German scientists
at the University of Wurzburg believe that they have found
the gene responsible for an inherited form of schizophrenia.
The gene was identified by studying three generations of an extended
German family in which many members suffered from catatonic schizophrenia,
an uncommon version of the disease which is characterised by
extreme physical effects. The gene is found on chromosome 22.
The German team thinks that there may be as many as 20 different
genes involved in schizophrenia. But other non-genetic factors,
such as viral infections during pregnancy, are probably involved.
DeCODE genetics of Iceland has dismissed the German researchers'
claim.
Source:
BioMedNet 20/3/2001 'Division is rife over schizophrenia gene
claim'
http://news.bmn.com/news/story?day=010320&story=1
Ö.but
the risk of older fathers
The risk to a child
of developing schizophrenia is thought to rise steadily as the
age of the father increases, say researchers at Columbia and
New York Universities and the Israeli Ministry of Health. They
reviewed
records of nearly 90,000 people born in Jerusalem between 1964
and 1976 and found that men between the ages of 45 and 49 were
twice as likely as those under 25 to have children who develop
schizophrenia. After the age of 50, the risk was increased threefold.
It is thought that the cause of the problem are sperm cells -
passed on to children - which can accumulate mutations as men
get older. The researchers believe that this may be the 'tip
of the iceberg' in terms of
conditions that may be linked to paternal age.
Source: CNN 13/4/2001 'Study shows male reproductive 'biological
clock''
- CNN:
http://www.cnn.com/2001/HEALTH/parenting/04/13/older.fathersreut/index.html
Gene to protect
against ovarian cancer?
Scientists
at the Queen's University and the Belfast City Hospital believe
that they have discovered a gene that protects women against
ovarian cancer by regulating the growth and multiplication of
cells. The discovery of the gene, which has taken three years,
could open up new avenues for diagnosis and treatment of ovarian
cancer, which is thought to affect 6,500 women each year in the
UK alone.
Your
face tells, you're smoking!
Scientists from Guys,
Kings and St Thomas' school of medicine believe that chemicals
in tobacco may activate a gene that expresses the protein matrix
metalloproteinase-1, or MMP-1, in the skin. This breaks down
collagen, a protein that maintains elasticity. Too much of this
enzyme would increase wrinkling and the ageing effect.
Source: The Times
23/3/2001 'Health Warning: smoking does wrinkle the skin'
http://www.thetimes.co.uk/article/0,,72-103915,00.html
Early
puberty gene discovered
Scientists in America
have discovered a gene that they believe might double the chances
of girls reaching puberty early, thought to be one possible reason
for an increased risk of breast cancer. It was reported at the
American Association for Cancer Research annual meeting in New
Orleans that nearly all girls carrying a specific gene variation
experienced puberty as young as nine years old.
The team of scientists found that the gene variant, called CYP1B1,
causes testosterone to be broken down twice as rapidly as normal
by enzymes in the liver, suggesting that the male sex hormone
may be more important in the sexual development of girls than
has been thought. Taking part in the study were 192 girls between
the ages of nine and 10.
Source: MSNBC 25/3/2001 'Gene may help explain early puberty'
http://www.msnbc.com/news/548914.asp
Do
blondes have more fun?
People with
blonde hair are being called for a study designed to show whether
blondes really do have more fun and why. A team of scientists
at Edinburgh University hope to discover why people have different
colour hair and how it might affect them. They want blondes of
all ages to take part in a two year research project aimed at
finding out more about the genetics of their hair colour.
The scientists are trying to find a gene that gives some people
blonde colouring in order to see what advantages having that
gene might bring, especially when it is known that having blonde
hair seems to make people more prone to sunburn and skin cancer.
Earlier work done by the team on red haired people seemed to
suggest that no evolutionary selection was at work, but that
the gene code for red was just 'genetic drift'.
Source: BBC News
Online 28/3/2001 'What is it about blondes?'
http://news.bbc.co.uk/hi/english/education/newsid_1248000/1248103.stm
On
the web
Contribute
to protein folding with your screensaver
Inspired by the
success of Seti@home, the screensaver that contributes to
searching among billions of signals for extraterrestial life,
Prof. Vijay Pande of Stanford University has developed Folding@home, a screensaver that
contributes to calculations of protein folding. The screensaver
shows the proteins that are being folded. Unfortunately, the
screensaver only works on PCs that have a direct connection to
Internet. Via the website of folding@home progress of the project can be followed.
The programme can be downloaded from:
www.foldingathome.stanford.edu
Quality
of Life Bulletin only on web
DG Research used
to send us the Quality of Life Bulletin, but as of recently it
is only available via the web. Visit:
www.cordis.lu/life
All
about genetic research
If you do not
want to miss anything concerning genes and genome research, visit
the freely available GeneLetter, full of interesting articles
and easy to navigate links:
www.geneletter.com
Key
info on ethics
The European
Commission has launched a website that guides researchers towards
the most important reference texts in the area of ethics in research:
http://www.cordis.lu/science-society
Latest
on BSE
A very useful
site chockfull of links and latest information about BSE, called
LinksDossier. Very comprehensive!:
http://www.euractiv.com/dossiers/ld_bse.htm
Harmonization
Regularly, the
Council of Europe's EDQM publishes proceedings of conferences
dealing with harmonised regulatory frameworks. Keep checking
their website for the most recent ones, such as one called 'current
developments in pharmaceutical analysis':
http://www.pheur.org
Partners
for Life
Partners for
Life is a new EU project that provides economic and technological
intelligence to SMEs. The aim is to offer targeted information
on technological and market trends in the field of life sciences
and to support their participation in European research projects,
in particular in biomedicine, biotechnology and agro-industry.
Groups of SMEs preparing innovative projects can receive up to
1 million EURO for research. Submission of joint projects is
possible until April 2002.
www.bit.ac.at/partners_for_life.htm
Funding
Information about
funding opportunities in Europe can be found at:
www.welcomeeurope.com
Publications
Nature
Genome Exclusive
Individual subscribers
to one of the many Nature publications received from the publisher
a commemorative copy of The Human Genome. Beautifully
printed, but if you didn't receive one: the entire content plus
additional features and commentary is available without restriction
on:
www.nature.com/genomics
The
facts about the human genome:
- the human genome
contains 2.91 billion base pairs;
- 1.1% of DNA
codes for proteins;
- 24% of DNA is
located in introns;
- 75% of DNA is
junk;
- there are 2.1
million SNPs, and fewer than 1% influences proteins;
- 26,383 genes
have been identified, and 42% has an unknown function;
- another 12,731
candidate genes have been identified;
- average size
of genes is 28,000 base pairs;
- chromosome 19
has more than 1,400 genes (23 genes per million base pairs),
but chromosome 13 has only 13 genes per million base pairs;
- 35% of the genome
contains repeating sequences;
- humans share
2,758 genes with Drosophila, 2,031 with Caenorhabdus, and 223
exclusively with bacteria;
- on average a
gene produces 3 different proteins;
Source: BioNieuws,
March 3, 2001
The
surprises of the human genome
The human genome
has produced a number of surprises. Here are 10:
- The genome is
like a wasteland with scattered cities: large 'deserts' of million
base pairs in which nothing is happening alternate with clusters
of active genes;
- We only have
approx. 31,000 genes, instead of the expected 100,000
- because of exons,
human genes can make three times as much protein per gene as
the genes of a simple organism;
- Most human proteins
are much more comples than the proteins of simpler organism,
containing several active domains;
- More than 200
human genes are the result of horizontal bacterial gene transfer.
These genes are not found in Drosophila, worms or yeast;
- Approximately
half of human DNA consists of repeating sequences, forming an
800 million year old archive;
- Selfish junk
DNA can be a nuisance, as the sequence Alu (200-300 bases) occurs
more than one million times in the genome;
- Mutation frequency
in men is twice as high as the mutation frequency in women;
- There is no
scientific basis for racial differences, since all human beings
are 99,9% equal to each other with respect to their DNA;
(10) The genome
already offers advantages in terms of discovery of disease-associated
genes (see also our 'Short Research News'.
New
Ernst & Young publication: convergence
Convergence between
research, finance and public opinion is positioning biotechnology
to become the most dynamic industry of the 21st century,
according to Ernst&Young's Biotechnology Report, Millenium
Edition: Convergence. The report cites advances in genomics as
a driving force behind investment, spurring activity. The report
notes that convergence in several areas, including information
technology, health care and various industial sectors, coupled
with new business models, has the potential to revolutionize
the biotechnology industry.
Copies from
Ernst & Young, 50 $ each, or read the Executive Summary online
at www.ey.com
Proposal FP 6
Goal:
to implement European Research Area
Recently, the
European Commission presented its proposal for a "multiannual
Framework Programme 2002-2006 of the European Community for Research,
Technological Development and demonstration activities aimed
at contributing towards the creation of the European Research
Area". In short, a proposal for a 6th Framework Programme
(FP 6). As the title shows, FP6 is meant to implement the European
Research Area. It is designed to:
(1) step up its
(ERAs) contribution to the development of scientific and technical
excellence in Europe, in EU countries and non-EU countries, both
in universities and in industry.
(2) increase
its impact on the innovation process in Europe;
(3) reinforce
its contribution to the efforts to integrate European Research.
Maximum
budget proposed is 16.270 million EURO.
Various institutions
will be consulted regarding this proposal. Proposals for specific
programmes will follow later. It is the intention that the Council
and the European Parliament will adopt FP 6 not later than the
first half of 2002.
Why
the European Research Area?
The European
Research Area (ERA) has become the reference framework for research
policy issues in Europe. It is seen as a central component to
promote innovation, competitiveness and employment, sustainable
economic growth and social cohesion in Europe.
The necessity
of ERA
is evidenced by:
(1) the EU's
major technological rivals are stepping up their efforts (US
public spending on research will grow by 9% in 2001);
(2) prospects
in life sciences and technologies are promising; the challenge
is to capitalize on the human genome;
(3) there is
a growing role for information and communication sciences;
(4) science holds
to a large extent the key to solving societal problems (i.e.
BSE);
(5) sustainable
development is a major political objective on the EU agenda.
Principle
of Framework Programme 6
The new FP will
be based on the following main principles:
I. concentrating
on a selected number of priority research areas in which
EU action can add the greatest possible value;
II. defining
the various activities in such a way as to enable them to exert
a more structuring effect on the research activities conducted
in Europe thanks to a stronger link with national, regional
and other European initiatives;
III. simplifying
and streamlining the implementation arrangements, on the
basis of the intervention methods defined and the centralised
management procedures envisaged: networks of excellence and integrated
projects will be administered to a large extent autonomously
by participants: to involve other partners, define small-scale
projects, adapt their programme of research to meet changing
needs. Certain aspects of the specific research activities and
support for researcher mobility will be entrusted to external
organisations operating under the Commission's responsibility.
Special efforts:
A special effort
will be made to maximise the dissemination of results and
to express them in terms that are readily understandable to decision
makers, so as to help them implement public policies.
Another special
effort will be made to increase the participation of women
in all activities of the programme.
All research
activities carried out under the FP 6 must be carried out in
compliance with fundamental ethical principles.
Two fundamental
new aspects are (1) the full participation of candidate countries
and (2) the opening up of EU research activities to the rest
of the world.The regional dimension of European research will
be fully taken into account.
Concentrating
(focusing) efforts
To ensure the
focusing of efforts, FP6 will be integrated around three targets:
1. Integrating
European research;
2. Structuring
the European Research Area;
3. Strengthening
the foundations of the European Research Area.
Target
1.
Integrating
European Research
(12.770
million EURO)
The bulk of FP6
efforts are intended to strengthen the scientific and technological
bases of Community industry. These activities will be carried
out:
1. In a limited
number of priority areas
by means of networks of excellence, integrated projects and EU
participation in national research programmes. Participation
of SMEs in networks of excellence and integrated projects should
be significant. Two new instruments will be introduced: a collective
research scheme and extension of 'cooperative research activities'.
International cooperation will be important.
2. In areas
related to the anticipation of EU science and technology needs
(help to anticipate emerging needs, react rapidly to new scientific
and technological developments and be present at the frontiers
of knowledge (annual decisions following calls for proposals,
choice of topics by the Commission)
3. In the field
of science and technology as a whole in the case of complementary
research activities for SMEs.
As a fundamental
general principle, competitive calls for proposals and evaluation
by means of peer review will be used to implement the bulk of
the activities.
Instruments to
integrate research are:
a. Networks
of excellence, characterised by a joint programme of activities,
precise research themes and topics, and activities to manage,
transfer and exploit the knowledge produced. Selection will be
on the basis of calls for proposals. A network of excellence
will involve several million EURO.
b. Integrated
projects will involve consortia with intense university/industry
collaboration. They should concern risky research and have clearly
defined objectives. Participation will be through calls for proposals.
Max support will be 50% of the proposed budget. A project may
involve tens of millions of EUROs.
c. Participation
in national programmes. The EU may contribute to national
programmes. Max support will be 50% of the proposed budget. This
new element will require a lot of consultation.
1.1.
Priority thematic areas of research
Seven thematic
areas have been selected. These have, within each of them, a
number of subjects linked to economic and societal issues that
are especially important to the EU and where its action adds
specific value for reasons which may vary according to the themes
in question. Some activities, particularly those intended to
help structure the European Research Area, will be opened up
to all themes and areas.
Activities are
intended to assemble a critical mass of resources and support
a high level of integration of research capacities in Europe
in areas in which this is especially necessary for the competitiveness
of European industry or the major political and social implications
of the issues in question. The seven priority thematic areas
are:
1. Genomics
and biotechnology for health (2 000 million EURO);
2. Information
Society Technologies (3,600 million EURO);
3. Nanotechnologies,
intelligent materials and new production processes (1,300 million
EURO);
4. Aeronautics
and space (1,000 million EURO);
5. Food safety
and health risks (600 million EURO);
6. Sustainable
development and global change (1,700 million EURO);
7. Citizens and
governance in the European knowledge-based society (225 million
EURO);
Genomics
and biotechnology for health
With respect
to genomics and biotechnology for health, the objectives are
to help Europe exploit, by means of an integrated research effort,
breakthroughs achieved in decoding the genomes of living organisms,
Ö.for the benefit of public health and citizens and to increase
the competitiveness of the European biotechnology industry.
Community activities
will address the following aspects:
1. fundamental
knowledge and basic tools for functional genomics: gene expression
and proteomics; structural genomics; comparative genomics and
population genetics; bioinformatics;
2. application
of knowledge and technologies in the field of genomics and biotechnology
for health: technological platforms for the development of new
diagnostic, prevention and therapeutic tools; support for innovative
research in genomics start-up companies;
3. application
of medical genomics knowledge and technologies in the
following fields: combating cancer, degenerative diseases of
the nervous system, cardiovascular diseases and rare diseases;
combating resistance to drugs; studying human development, the
brains and the ageing process.
A broader approach
will be pursued with regard to combating the three poverty-linked
infectious diseases (AIDS, malaria and tuberculosis), which have
priority in terms of disease control at EU and international
level.
Other themes
of interest
Other priority
themes with topics of interest are:
Nanotechnologies, which aim to achieve
a critical mass of capacities needed to develop and exploit,
especially for greater eco-efficiency, leading-edge technologies
for the knowledge and intelligence-based products, services and
manufacturing processes of the years to come.
Actions envisaged
include applications of nanobiotechnologies in areas such as
health, chemistry, energy, optics and the environment.
Food safety
and health risks
include, among others, methods of analysis and detection of chemical
contaminants and pathogenic microorganisms (incl. prions)
The final theme,
citizens and governance, includes such a wide variety of topics
as improving the production, transmission and utilisation
of knowledge in Europe; transnational research and comparative
studies; interdisciplinary research in support of public policies;
and the establishment and exploitation on a European scale of
research infrastructures and data and knowledge bases.
1.2. Anticipating
the EUs scientific and technological needs (2,345 million EURO)
Objective: respond
to the scientific and technological needs of the policies
of the Community;
Respond more
flexibly and rapidly to emerging scientific and technological
needs and major unforeseeable developments, as well as needs
appearing at the frontiers of knowledge.
The activities
will address the following themes:
1. Activities
carried out on the basis of calls for proposals
a. In particular
research in support of common policies, EU objectives
b. Research that
responds to needs in new areas at the leading edge of knowledge.
Activities will
essentially take the form of:
1. Specific targeted
projects generally of a limited scale;
2. The networking
of research activities carried out at national level
The choice of
research topics will be made by the Commission on the basis of
assessment by an internal group of users
These activities
will also comprise, in particular, specific research activities
for SMEs:
(i). Collective
research activities (by technical research centres of industrial
associations or industry groupings in entire sectors of industry
dominated by SMEs at the European level;
(ii). Cooperative
research activities by research centres for a number of SMEs
on themes of common interest
2. Joint Research
Centre Activities
Target
2.
Structuring
the European Research Area (3,050 million EURO)
a. Research
and innovation: stepping up economic and technological intelligence
activities, utilisation of research results, transfer of knowledge,
setting up of technology businesses in Europe. (300 million EURO)
b. Human resources
and mobility. More funding, making Europe more attractive
to third-country researchers, and support schemes for excellent
EU research teams. (1,800 million EURO)
c. Research
infrastructures of the highest level in Europe and promote
their optimal use on a European scale. Broadband communication
infrastructures, transnational access, networking. (900 million
EURO)
d. Science/society:
activities to encourage harmonious relations between science
and society and the opening up of innovation in Europe as a result
of the establishment on new relations and an informed dialogue
between researchers, industrialists, political decision makers
and citizens (50 million EURO)
Target
3.
Strengthening
the foundations of the European Research Area (450 million EURO)
The activities
are intended to step up the coordination and support the coherent
development of research and innovation-stimulation policies and
activities in Europe. The activities will take the following
form:
a. Strengthening
coordination of research: mutual opening up of research
programmes, networking of research activities conducted at national
level, scientific and technological cooperation activities, collaboration
and joint initiatives of CERN, EMBL, ESO and ESA;
b. Supporting
the development of coherent research and innovation policies:
analyses and studies, specialised working groups, forums for
concertation and political debate, benchmarking of research and
innovation policies, mapping of scientific and technological
excellence.
References:
The full text
of the proposal can be downloaded from the CORDIS website (http://www.cordis.lu)
or you can request a copy from the IVTIP Secretariat.
Reference:
COM (2001) 94 final, Brussels, 21.2.2001 for explanatory memorandum,
reference 2001/0053 (COD) for RTD proposal itself.
AGENDA
A number of
interesting conferences and workshops is coming up. Of all the
events mentioned here, the detailed programmes and registration/application
forms are available from the ACTIP secretariat.
.
Industrial &
Intellectual Property Conference
May 10-11, 2001,
Brussels
Organization: Competence
Promotion Center. Tel + 32 2 237 09 00; fax: + 32 2 230 46 49.
www.competence.ibf.be
GMP compliance
in Europe
May 10-11, 2001,
Brussels
Organization: EDQM,
fax: + 33 388 41 27 71; tel: + 33 388 41 28 15. Web: www.pheur.org
10th International
Congress for Human genetics
May 15-19, 2001,
Vienna, Austria
Organization: HYPERLINK
mailto:jderoos@rose-international.com jderoos@rose-international.com
Impact of genomics
on Medicine
May 21-22, 2001,
Munich, Germany
Organisation: Cambridge
HealthTech Institute, email: chi@healthtech.com or www.healthtech.com
Early drug target
validation
May 21-22, 2001
Geneva, Switzerland
Organization: Vision
in Business Ltd. Tel + 44 20 7256 5188
Technology Commercialisation:
Developing Biotech Start-ups
May 23, 2001,
London UK
Organization: SMI
Pharmaceutical Conferences. Tel + 44 207 252 22 22
From genes to
drugs: innovations in cardiovascular therapeutics
May 23-24, San
Diego
Organization: SMI
Pharmaceutical Conferences. www.smi-online.co.uk/genes.asp
Biologic 2001
Delivering integrated
scale-up and manufacturing solutions
June 4-6, Geneva,
Switzerland
Organization: ECPI:
HYPERLINK http://www.ecpi-online.com www.ecpi-online.com, or
Nicola McCall on +44 20 7827 5965
8th International
Inhalation Symposium
Drug research
and clinical inhalation
June 6-9, 2001
Hannover Germany
Organization: fraunhofer
Institute of Toxicology. www.ita.fhg.de. Tel + 49 511/53 50 121
17th ESACT meeting
From target to
market
June 10-14, 2001,
Tylösand, Sweden
Organization: ESACT
Secretariat, fax + 46 8 730 06 99; email: www.esact.org
Protein Biotechnology
in the 21st Century
June 11-15, 2001,
Amersfoort, The Netherlands
Organization: Dutch
Royal Society of Chemistry: www.bloup.com
EMBO long-term
fellows meeting
24 - 27 June,
EMBL, Heidelberg, Germany.
Organization: EMBO, Francoise Degrasse, Heidelberg
francoise.degrasse@embo.org
Fax: +49-6221-8891200
Programme at: http://www.embo.org/FM01.html
BIO's International
Convention and Exhibition
June 24-27, 2001,
San Diego, California
Organization: BIO.
www.bio.org or Tel + 1 202 857 02 44
10th European Congress
on Biotechnology (ECB 10)
July 8-11, 2001,
Madrid, Spain</P>
Organization: EFB,
Dechema
43rd International
Meeting of the European Tissue Culture Society
5th Gene Delivery
& Cellular Protein Expression Conference
September 9-13,
2001, Vienna, Austria
Organization: Reingard
Grabherr, University of Agriculture, Austria. Email: HYPERLINK
mailto:r.grabherr@iam.boku.ac.at r.grabherr@iam.boku.ac.at
ACTIP annual
plenary meeting
September 20-21,
York, UK
Organization: ACTIP
Secretariat: www.ACTIP.org
15th Forum for
Applied Biotechnology
Sept 24-25, 2001,
Gent, Belgium
Organization: GOM-West-Vlaanderen;
tel + 32 50 36 71 31; fax; + 32 50 36 31 86
Cell Interactions
and Cellular Complexity
Sept 30-October
3, 2001, Granada, Spain
Organization: European
Tissue Culture Society. web: www.san.gva.es/centros/lafe/ETCS/ETCS_ESP-granada-2001-00.html
Vaccines of the
future: from rational design to clinical development
October 17-19,
2001, Paris France
Organization: Institut
Pasteur Euroconferences. Fax: + 33 1 40 61 34 05. www.pasteur.fr/applications/euroconf
Genome 2001-05-02
22-24 October
2001, London
Organization: ECPI.
Fax: + 44 20 7242 1508
Second European
Meeting on Cell Engineering
October 26-28,
2001, Costa Brava, Spain</P>
Organization: Dr.
Mohammed Al-Rubai, Dr. David lLoyd: email: D.R.Lloyd@bham.ac.uk; http://www.bham.ac.uk/ChemEng/actg/ewce2.htm
9th meeting of
the European Society of Gene Therapy
November 2-4,
2001, Antalya, Turkey
Organization: Congrex
Sweden AB, email esgt@congrex.se, or the congress manager, email:
binanc@serenas.com.tr
Pharmaceutical
products and viral safety
March 14-15,
2002, Paris France
Organization: Institut
Pasteur Euroconferences. Fax: + 33 1 40 61 34 05. www.pasteur.fr/applications/euroconf
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