Photo: GSK Marburg

ACTIP News Bulletin

Latest version:

• ACTIP Bulletin 72 (October 2017), including the latest agenda of interesting events.

The following ACTIP bulletins are still available online. Older bulletins can be requested from the ACTIP Secretariat

Bulletin 71 (April 2015)

• Bulletin 70 (November 2014)

• Bulletin 69 (May 2014)

Biologics on the market

Historically, biologics were produced from a biological source, such as tissues, organs or eggs. Since the late 1970s, however, they are increasingly made using animal cell technology. By now, more than 80 biopharmaceuticals made in animal cells have received marketing approval from either the FDA or EMA. Here we present three tables listing approved products:
(1) a list of biopharmaceuticals produced with animal cell technology and approved for marketing since 1978;
(2) a list of vaccines produced with animal cell technology and approved for marketing since 1969;
(3) a list of biopharmaceuticals derived from tissues or organs and approved for marketing since 1966.

At present, new biopharmaceuticals often are monoclonal antibodies (mab’s). Here we present a fourth list, giving all therapeutic monoclonal antibodies approved for marketing since 1986 until 2017 (last update: May 2017).

Gene therapy products

If you would like to know which gene therapy products have been or are being tested, please follow this link to a gene therapy monograph.

ACTIP monographs and other publications

Biomanufacturing 2020 IMI-2 topic (last update January 2017)

• ACTIP Information paper (last update: November 2011)

• ACTIP Position paper (last update: January 2012)

• Animal Cell Technology (last update: March 2016)

• Biotechnology and biopharmaceuticals (last update: March 2016)

• Past, present and future of monoclonal antibodies (last update: June 2013)

• Vaccines and animal cell technology (last update: June 2013)

Stem cells (last update: Dec. 2016)

• Safety Testing of Recombinant Protein Products Derived from Cell Lines of Human and Animal Origin (last update: April 2014)

• ACTIP 1990 – 2010 (ACTIP’s 20th anniversary publication, 2010)

Background documents

• What is Animal Cell Technology

Download here a review on:
Optimal and consistent protein glycosylation in mammalian cell culture.
By Hossler et al, Glycobiology, vol 19 no 9 pp 936-949, 2009

©2017 ACTIP

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